Antioxidant, Antiplatelet and Antimicrobial Activities of Ajuga Bracteosa against Various Pathogens
نویسندگان
چکیده
This study was carried out to evaluate the Brine shrimp lethality (cytotoxicity), antiglycation, phytotoxicity, antiplatelet, antifungal, and antibacterial activities of Ajuga bracteosa. The n-hexane fraction of Ajuga bracteosa was investigated for various biological activities in vitro. Hexane extract showed promising phytotoxicity (100%) at the highest dose only. Interestingly, n-hexane fraction showed 100% antiplatelet activity against AA (48 μg/mL) and PAF (15 μg/mL) but it was inactive against pathogenic bacteria and fungi used in the antibacterial and antifungal assays. The antioxidant potential of n-hexane fraction was evaluated by its potential to scaveng superoxide anion radical, DPPH (2,2-diphenyl-1picrylhydrazyl) free radical, and the lipid peroxidation assays. The results showed that n-hexane fraction exhibit moderate activity against lipid peroxidation, DPPH, and superoxide assays. In conclusion, the n-hexane fraction of A. Bracteosa possess a strong biological role, which suggest the presence of bioactive metabolites.
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